Peptide Database

Peptide NameSLAY-screened peptide P276

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC88H138N26O37S2

DescriptionStandard

        QSTTLHTTCGYMSNENDEKG
    

Molecular Weight2216.32 Da

Isoelectric Point (pI)4.65

Net Charge (pH 7.0)-2.16

Net Charge (pH 7.4) -2.43

Charge Density (pH 7.0) -0.1079

GRAVY Index-1.32

Hydrophobic Moment 0.21

Boman Index-0.20

Instability Index63.15

Aliphatic Index 19.50

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1053.70

LogP -16.63

H-bond Donors 37.0

H-bond Acceptors 38.0

Rotatable Bonds 74.0

Heavy Atoms 153.0

Ring Count 2.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0403644 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/