Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length499 amino acids

Chemical FormulaC2466H3932N630O710S22

DescriptionStandard

        MCVTDSAGNTMPLWCLLVLLALPDPTVTTNPGVKVQITQQGLDYGRQIGIAYLQEKLKSISIPDISGSEKVSPIGKVEYRLSGMRITDLGLPQSSLGLVPGTGISLSIGNAFINLHGDWHVKYLKFIKDSGSFDLAVSGLTIKATISVGRDETGRPTISSNGCTASVGGVRVKFHGGASWLYNLFTSFIEKQLRRSLEQKICPLVHDGISDLNPQLKTLNVLAKVDKYAEIEYSMVTPPSISNFLIELSLKGEFYNIGQHQEPPFSAPPFSLPPQTSSMLYIGLSSFMANSAGFVYNRAGALSLYITDDMVPSSSPIRLNTKTFGVFIPEISKRFPDMMMKLLLKTSTQPNVTFEPNNVTLQATGTLTAYAILPNTTLEPLFILNMDASVSGNFYISGLKLVGSLQLNGFDMSLGTSYVGEFQVKPLHNIFMLVMKLAVIPKVNEYLQQGFPLPAIGRMNLINSKLQVQKVRLVTPQKPDKCSMLKLHLCSSLFQAVIS
    

Molecular Weight54470.82 Da

Isoelectric Point (pI)9.00

Net Charge (pH 7.0)8.07

Net Charge (pH 7.4) 7.31

Charge Density (pH 7.0) 0.0162

GRAVY Index0.13

Hydrophobic Moment 0.73

Boman Index0.16

Instability Index36.90

Aliphatic Index 100.76

Aromaticity 0.0822

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39225.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0403724 VERIFIED: NO

Provenance & Taxonomy

OrganismParamormyrops kingsleyae [Bacterium]

FamilyBPI

Tax ID1676925

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence