Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length443 amino acids

Chemical FormulaC2191H3500N528O660S13

DescriptionStandard

        MRTKQVPVLWACFLLWNLFVSSSQTANPGIKARITQRALDYGVQVGMKIMEEMAKEIVIPDLKGSESLEFLKIDYVKYNFSNIKINAFSMPNTSLAFVPGVGIRALSNHGTANISANWEVRAPLFQDSGAADLFLSGIYFTGIIVLARNNVGHPVLELQDCYVQVSHARVSFSGGLSVLYNSFAEPMEKPILRNLNEMLCPMVINEVEALNVNISALEVLTKIDNYTVLDCSLISPPEITENHLDLNLKGAFYPVESLVDPPFLPAPFELPQSGDSMLYIGISEYFFKSASFAHYVSGALGITLSTKEVSYFTTTTTTITAITIIITTTTTITTTTIITITIITTIITIITTITTTTTTTTTTIITTTITTTTTIITIITTIITTTITIIITTITTTTTTIITIITTITTSTTTNNNNYHPIPPQSPLSPPLPLPSPPPPPPS
    

Molecular Weight48215.21 Da

Isoelectric Point (pI)5.17

Net Charge (pH 7.0)-8.98

Net Charge (pH 7.4) -9.63

Charge Density (pH 7.0) -0.0203

GRAVY Index0.34

Hydrophobic Moment 0.73

Boman Index0.24

Instability Index37.38

Aliphatic Index 106.95

Aromaticity 0.0767

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0386587 VERIFIED: NO

Provenance & Taxonomy

OrganismMicrotus ochrogaster [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence