Peptide Database

Peptide NameH2-3

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC113H160N30O21

DescriptionStandard

        HGLLYFAIFFVAAWHIRGR
    

Molecular Weight2274.67 Da

Isoelectric Point (pI)10.84

Net Charge (pH 7.0)1.93

Net Charge (pH 7.4) 1.63

Charge Density (pH 7.0) 0.1018

GRAVY Index0.85

Hydrophobic Moment 0.26

Boman Index0.40

Instability Index35.14

Aliphatic Index 113.16

Aromaticity 0.2632

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 804.30

LogP -0.85

H-bond Donors 30.0

H-bond Acceptors 25.0

Rotatable Bonds 68.0

Heavy Atoms 164.0

Ring Count 8.0

Amide Bonds 18.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0426271 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HCV

TargetH2-3 peptide inactivated HCV

Activity0.08211 μM

MethodEC50

Half-LifeMammalian: 3.5 h; Yeast: 10 min; E. coli: >10 h

PaperA p7 Ion Channel-derived Peptide Inhibits Hepatitis C Virus Infection in Vitro. | Hong W, Lang Y, Li T, Zeng Z, Song Y, Wu Y, Li W, Cao Z. | J Biol Chem. 2015 Sep 18;290(38):23254-63. | DOI:10.1074/jbc.M115.662452 | PMID:26251517 PMID26251517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26251517/

FIRST PREV 1 2 3 4

Showing 1 records on this page Ã‚Â· Page 4 of 4