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MYP_090633
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Basic Information
H2-3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
19 amino acids
C113H160N30O21
Standard
Sequence
HGLLYFAIFFVAAWHIRGR
Physicochemical Analysis
2274.67 Da
10.84
1.93
1.63
0.1018
0.85
0.26
0.40
35.14
113.16
0.2632
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
804.30
-0.85
30.0
25.0
68.0
164.0
8.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0343006 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
cells
115
CC50
PaperPubMed PMID: 26251517 PMID26251517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26251517/
RECORD: Rec_0357888 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
HeLa cells
~200 μM
CC50
PaperPubMed PMID: 26251517 PMID26251517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26251517/
RECORD: Rec_0381539 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Infection inhibition
Inhibition of post-infection in Huh7.5.1 cells
1.09±0.11 μM
EC50
Mammalian: 3.5 h; Yeast: 10 min; E. coli: >10 h
PaperA p7 Ion Channel-derived Peptide Inhibits Hepatitis C Virus Infection in Vitro. | Hong W, Lang Y, Li T, Zeng Z, Song Y, Wu Y, Li W, Cao Z. | J Biol Chem. 2015 Sep 18;290(38):23254-63. | DOI:10.1074/jbc.M115.662452 | PMID:26251517 PMID26251517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26251517/
RECORD: Rec_0392258 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
H2-3 peptide inactivated HCV
0.08211 μM
EC50
PaperPubMed PMID: 26251517 PMID26251517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26251517/
RECORD: Rec_0406035 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
cells
1.09±0.11 μM
EC50
PaperPubMed PMID: 26251517 PMID26251517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26251517/
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