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MYP_090615
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Basic Information
M2 MH
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
18 amino acids
C123H199N35O20
Standard
Sequence
RKFFKKIYRFFRKLLKRL
Physicochemical Analysis
2488.12 Da
12.00
8.75
8.54
0.4863
-0.65
1.05
-0.45
-4.34
86.67
0.2778
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
955.95
-1.56
37.0
29.0
89.0
178.0
5.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0216613 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
H1N1(A/Swine/Iowa/15/30):inhibition of infection in Madin-Darby canine kidney epithelial(MDCK) cells
0.053 μM
IC50
PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
RECORD: Rec_0251896 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
H3N2(A/Sydney/5/97):inhibition of infection in Madin-Darby canine kidney epithelial(MDCK) cells
0.058 μM
IC50
PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
RECORD: Rec_0262205 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
H1N1(A/Puerto Rico/8/34):inhibition of infection in Madin-Darby canine kidney epithelial(MDCK) cells
0.053 μM
IC50
PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
RECORD: Rec_0295068 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Madin-Darby canine kidney epithelial(MDCK) cells:CC50=19
PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
RECORD: Rec_0310500 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-H3N2 Infection inhibition
H3N2 (A/X31)
0.016 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperEnvelope-deforming antiviral peptide derived from influenza virus M2 protein. | Jung Y, Kong B, Moon S, Yu SH, Chung J, Ban C, Chung WJ, Kim SG, Kweon DH. | Biochem Biophys Res Commun. 2019 Sep 24;517(3):507-512. | DOI:10.1016/j.bbrc.2019.07.088 | PMID:31375212 PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
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