Peptide Database

Peptide NamehBD-28

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC178H301N55O48S6

DescriptionStandard

        ARLKKCFNKVTGYCRKKCKVGERYEIGCLSGKLCCAN
    

Molecular Weight4172.02 Da

Isoelectric Point (pI)9.54

Net Charge (pH 7.0)7.73

Net Charge (pH 7.4) 7.44

Charge Density (pH 7.0) 0.2090

GRAVY Index-0.40

Hydrophobic Moment 0.60

Boman Index-0.22

Instability Index-0.22

Aliphatic Index 63.24

Aromaticity 0.0811

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1720.46

LogP -17.82

H-bond Donors 68.0

H-bond Acceptors 62.0

Rotatable Bonds 147.0

Heavy Atoms 287.0

Ring Count 3.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412940 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide6-34, 14-28, 18-35

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli DSM1103

Activity37.5 μg/mL

MethodMIC

RECORD: Rec_0420923 VERIFIED: YES