Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2307H3676N584O674S18

DescriptionStandard

        MILSWCLVLVTFTSTTFGTNPGVQVRLTQKGLEYGRQMGIISLQQKLGSVTIPDFSGSQSVSPIGNVKYSLTNINLVNVGLPKSALDLVPGTGVRLSIGDAFMSLHGDWRVKYLHVIKDSGSFDVNVNGLSITTSIAVSSDETGRPAVDVASCAASVASAEVKFHGGASWLYNLFSNFIDKALRDALQEQICPLVVKAVADLNPTLKTLNVLAKVDKYAEIEYSMVSSPIVAASSLDLSLKGEFYNIGKHQEPPFSPAAFSLPPQTDNMVYIALSAFTPNSAGFVYNKAGVMSLYITDDMVPKESPVRLNTNTFGVFIPQIKKQFPGLMMKLLLKTSDNPTIAFQPKNATVEVTGTMTAYAIQPNGTLSPLFVLNMESSVSADVFVSGLNIAGRVSLNRMKLTLATSYVGLFQVSTLNSIFQTILKVVVIPEVNVQLAKGYPLPALGKMNLVKPQVHLMKDYMLIGTDVTFTA
    

Molecular Weight50954.54 Da

Isoelectric Point (pI)8.71

Net Charge (pH 7.0)3.92

Net Charge (pH 7.4) 3.31

Charge Density (pH 7.0) 0.0083

GRAVY Index0.25

Hydrophobic Moment 0.78

Boman Index0.19

Instability Index32.77

Aliphatic Index 102.16

Aromaticity 0.0825

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37485.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0289591 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius korthausae [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria