Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length163 amino acids

Chemical FormulaC824H1255N207O250S6

DescriptionStandard

        YSWLYNLFKHLIENNIRDHLKGQLCDQVTEAINSDLENSLQEISITAKVDEFTEVDYSLLSPPDTRADMLDIPCKGEFYSLQHHSEFPVPAPPMDLGTSADRMLYFGLSEFLFNSAGYAYQASGALTYIITEAMLPKDAPFHINTSSLAPIAVKVHRSAPQPL
    

Molecular Weight18253.41 Da

Isoelectric Point (pI)4.74

Net Charge (pH 7.0)-10.71

Net Charge (pH 7.4) -11.29

Charge Density (pH 7.0) -0.0657

GRAVY Index-0.17

Hydrophobic Moment 0.61

Boman Index0.10

Instability Index45.74

Aliphatic Index 88.65

Aromaticity 0.1043

Extinction Coeff. Reduced 17420.00

Extinction Coeff. Oxidized 17545.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7234.23

LogP -65.38

H-bond Donors 244.0

H-bond Acceptors 251.0

Rotatable Bonds 584.0

Heavy Atoms 1287.0

Ring Count 36.0

Amide Bonds 175.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0214542 VERIFIED: NO

Provenance & Taxonomy

OrganismPetromyzon marinus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence