Peptide Database

Peptide NameSLAY-screened peptide P188

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC94H150N34O32S2

DescriptionStandard

        PSHGLDSSRRTHCNYIRTCE
    

Molecular Weight2332.54 Da

Isoelectric Point (pI)8.44

Net Charge (pH 7.0)1.12

Net Charge (pH 7.4) 0.93

Charge Density (pH 7.0) 0.0561

GRAVY Index-1.21

Hydrophobic Moment 0.57

Boman Index-0.38

Instability Index71.47

Aliphatic Index 39.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1084.36

LogP -15.76

H-bond Donors 43.0

H-bond Acceptors 37.0

Rotatable Bonds 75.0

Heavy Atoms 162.0

Ring Count 4.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0362183 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/