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MYP_090250
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Basic Information
c8
Anticancer
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
5 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KWXKK
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0250802 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Lactam
Lactam
X=p-CF3-Bzl-
Bio-Activity Profile
Antimicrobial Anticancer
Ramos
12.6±0.6 μM
IC50
PaperPubMed PMID: 22933412 PMID22933412 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22933412/
RECORD: Rec_0330381 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Lactam
Lactam
X=p-CF3-Bzl-
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
human erythrocytes
298 μM
EC50
PaperPubMed PMID: 22933412 PMID22933412 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22933412/
RECORD: Rec_0374418 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Lactam
Lactam
X=2-Nal-CH2-
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 22933412 PMID22933412 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22933412/
RECORD: Rec_0377474 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
(2,2-di(naphthalen-2-ylmethyl)-3-amino-propionic acid)
Bio-Activity Profile
Anticancer
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0390712 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Lactam
Lactam
X=p-CF3-Bzl-
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MRC-5
53±2 μM
IC50
PaperPubMed PMID: 22933412 PMID22933412 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22933412/
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