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MYP_090249
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Basic Information
Brevinin-1HB1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
24 amino acids
C122H206N28O26S3
Standard
Sequence
FLPAIIGMAAKVLPAFLCKITKKC
Physicochemical Analysis
2577.31 Da
9.70
3.74
3.50
0.1557
1.20
0.48
0.38
39.75
126.25
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
839.35
-1.80
30.0
33.0
84.0
179.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0187328 VERIFIED: YES
Provenance & Taxonomy
Pelophylax hubeiensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antioxidant Anti-Gram-negative
Escherichia coli
37.5 μM
MIC
RECORD: Rec_0205362 VERIFIED: YES
Provenance & Taxonomy
Pelophylax hubeiensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Enterococcus faecalis 981
9.4 μM
MIC
PMID28402481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28402481/
RECORD: Rec_0218316 VERIFIED: YES
Provenance & Taxonomy
Pelophylax hubeiensis [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0257219 VERIFIED: YES
Provenance & Taxonomy
Pelophylax hubeiensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Antioxidant
N. asteroides 201118
1.2 μM
MIC
PaperIdentification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. PMID28402481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28402481/
RECORD: Rec_0261741 VERIFIED: YES
Provenance & Taxonomy
Pelophylax hubeiensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Antioxidant
Staphylococcus aureus ATCC 25923
4.7 μM
MIC
PaperIdentification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. PMID28402481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28402481/
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