Peptide Database

Peptide NameRegenerating islet-derived protein 3-alpha (REG-3-alpha) (Hepatointestinal pancreatic protein) (HIP PAP) (Human proislet peptide) (Pancreatitis-associated protein 1) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into: Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenerating islet-derived protein 3-alpha 15 kDa form]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Binding / Molecular interaction ▸ Carbohydrate-binding peptide ▸ Lectin

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length175 amino acids

Chemical FormulaC862H1315N231O256S12

DescriptionStandard

        MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD
    

Molecular Weight19394.84 Da

Isoelectric Point (pI)7.56

Net Charge (pH 7.0)0.71

Net Charge (pH 7.4) 0.20

Charge Density (pH 7.0) 0.0041

GRAVY Index-0.25

Hydrophobic Moment 0.57

Boman Index0.05

Instability Index49.93

Aliphatic Index 71.31

Aromaticity 0.1086

Extinction Coeff. Reduced 48930.00

Extinction Coeff. Oxidized 49305.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7734.84

LogP -83.15

H-bond Donors 277.0

H-bond Acceptors 272.0

Rotatable Bonds 614.0

Heavy Atoms 1361.0

Ring Count 42.0

Amide Bonds 186.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0284675 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-positive Lectin Non-hemolytic

TargetGram Positive Bacteria