Peptide Database

Peptide Name80-94

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC72H114N16O26S2

DescriptionStandard

        ILMCFSIDSPDSLEN
    

Molecular Weight1683.90 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-3.24

Net Charge (pH 7.4) -3.46

Charge Density (pH 7.0) -0.2163

GRAVY Index0.39

Hydrophobic Moment 0.25

Boman Index0.22

Instability Index72.12

Aliphatic Index 104.00

Aromaticity 0.0667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 677.61

LogP -6.53

H-bond Donors 23.0

H-bond Acceptors 25.0

Rotatable Bonds 54.0

Heavy Atoms 116.0

Ring Count 2.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0390198 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-RSV Entry inhibition

TargetRespiratory syncytial virus (RSV) | HEp-2 cells

Activity1.75 μM

MethodIC50

Half-LifeMammalian: 20 h; Yeast: 30 min; E. coli: >10 h

PaperAntiviral activity of RhoA-derived peptides against respiratory syncytial virus is dependent on formation of peptide dimers. | Budge PJ, Lebowitz J, Graham BS. | Antimicrob Agents Chemother. 2003 Nov;47(11):3470-7. | DOI:10.1128/AAC.47.11.3470-3477.2003 | PMID:14576104 PMID14576104 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14576104/

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