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MYP_090189
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Basic Information
KR-20
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
20 amino acids
C109H190N36O29
Standard
Sequence
KRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
2468.90 Da
11.55
3.76
3.55
0.1881
-0.76
0.97
-0.41
54.46
107.00
0.0500
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1108.31
-9.98
40.0
33.0
86.0
174.0
2.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0150220 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus ATCC 25923
64 μM
MIC
PMID14978112 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14978112/
RECORD: Rec_0154464 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus mprF
16 μM
MIC
PMID14978112 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14978112/
RECORD: Rec_0218082 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans ATCC 14053
10 μM
MIC
PMID14978112 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14978112/
RECORD: Rec_0225239 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1IIIB | CEM-SS cells
40.5 μM
EC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins. | Wang G, Watson KM, Buckheit RW Jr. | Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. | DOI:10.1128/AAC.00452-08 | PMID:18591279 PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/
RECORD: Rec_0237482 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli O29
64 μM
MIC
PMID14978112 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14978112/
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