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MYP_090178
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Basic Information
Casein alpha-s1 [099-109]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
11 amino acids
C66H116N18O14
Standard
Sequence
LRLKKYKVPQL
Physicochemical Analysis
1385.74 Da
10.46
3.76
3.55
0.3415
-0.64
0.24
-0.29
46.18
132.73
0.0909
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
548.81
-1.59
19.0
18.0
48.0
98.0
2.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0288153 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic Cytotoxic
PMID29783753 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29783753/
RECORD: Rec_0291413 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
alpha-S1-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperAn antimicrobial peptide screened from casein hydrolyzate bySaccharomyces cerevisiae cell membrane affinity method | Tang, W. et al. | DOI: 10.1016/j.foodcont.2014.09.030 Evidence URLhttps://www.uniprot.org/uniprotkb/P02662/entry
RECORD: Rec_0313711 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic Cytotoxic
In 293 cells, The peptide had no cytotoxic activity at concentrations of 1-512 μM
PMID29783753 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29783753/
RECORD: Rec_0368771 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli UB1005
128 μM
MIC
PMID29783753 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29783753/
RECORD: Rec_0395463 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
alpha-S1-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli; Staphylococcus aureus; Listeria monocytogenes
64-640 μM
MIC
PaperBroad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine αS1-Casein | Hou, J. et al. | DOI: 10.3390/molecules23051220 Evidence URLhttps://www.uniprot.org/uniprotkb/P02662/entry
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