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MYP_090133
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Basic Information
PaDef
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
45 amino acids
C203H329N71O61S9
Standard
Sequence
CETPSKHFNGLCIRSSNCASVCHGEHFTDGRCQGVRRRCMCLKPC
Physicochemical Analysis
5028.81 Da
8.77
3.95
3.47
0.0877
-0.46
0.41
-0.19
51.17
41.11
0.0444
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2136.27
-29.16
84.0
77.0
165.0
344.0
7.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037110 VERIFIED: YES
Provenance & Taxonomy
Persea americana var. drymifolia [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported, sites unresolved
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli; Staphylococcus aureus
Antibacterial activity assay
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID24319695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0057087 VERIFIED: YES
Provenance & Taxonomy
Persea americana var. drymifolia [Plant]
Defensin
Structure & Mods
linear disulfide-rich peptide [Linear]
stereochemistry not specified [Other]
Disulfide bond(s) reported, sites unresolved
Bio-Activity Profile
Anticancer Cytotoxic
MCF-7 cells; K562 cells; Jurkat cells
Cell viability/cytotoxicity assay
PMID27470405;29559362;35141282
RECORD: Rec_0064395 VERIFIED: YES
Provenance & Taxonomy
Persea americana var. drymifolia [Plant]
Defensin
Structure & Mods
linear disulfide-rich peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported, sites unresolved
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MCF-7 cells; K562 cells; Jurkat cells
Cell viability/cytotoxicity assay
PMID27470405;29559362;35141282 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24319695/
RECORD: Rec_0175834 VERIFIED: YES
Provenance & Taxonomy
Persea americana var. drymifolia [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported, sites unresolved
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MCF-7 cells; K562 cells; Jurkat cells
Cell viability/cytotoxicity assay
PaperAntibacterial Activity of Defensin PaDef from Avocado Fruit (Persea americana var. drymifolia) Expressed in Endothelial Cells against Escherichia coli and Staphylococcus aureus PMID27470405;29559362;35141282
RECORD: Rec_0311131 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Designed peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ade notation
Bio-Activity Profile
Antimicrobial