Peptide Database

Peptide NameHYL-10

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC81H153N21O19S2

DescriptionStandard

        GIMSSLMKKLAKIIKK
    

Molecular Weight1789.34 Da

Isoelectric Point (pI)10.60

Net Charge (pH 7.0)4.76

Net Charge (pH 7.4) 4.54

Charge Density (pH 7.0) 0.2972

GRAVY Index0.33

Hydrophobic Moment 0.82

Boman Index0.05

Instability Index27.65

Aliphatic Index 128.12

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 670.38

LogP -3.31

H-bond Donors 24.0

H-bond Acceptors 26.0

Rotatable Bonds 69.0

Heavy Atoms 123.0

Ring Count 0.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0317933 VERIFIED: YES

Provenance & Taxonomy

OrganismHylaeus signatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus 6271

Activity33 μM

MethodMIC

RECORD: Rec_0326883 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetStaphylococcus epidermidis

Activity2.9 μM

MethodMIC

PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129. PMID: 26998557. PMID26998557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26998557/

RECORD: Rec_0354333 VERIFIED: YES

Provenance & Taxonomy

OrganismHylaeus signatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus epidermidis

Activity2.9 μM

MethodMIC

RECORD: Rec_0418129 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129. PMID: 26998557. PMID26998557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26998557/

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