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MYP_090081
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Basic Information
Angiotensin I-converting enzyme inhibitor HG
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
2 amino acids
C8H12N4O3
Standard
Sequence
HG
Physicochemical Analysis
212.21 Da
6.74
-0.15
-0.41
-0.0764
-1.80
0.34
0.04
-46.85
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
121.10
-1.52
4.0
4.0
5.0
15.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0086506 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Cytotoxic Anticancer
HT29 cells
70-80 %
Percent inhibition assay
PMID22574992 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22574992/
RECORD: Rec_0088210 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory Enzyme inhibitory
Angiotensin-converting enzyme (ACE)
6300.0
IC50
PaperCheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.. Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407.
RECORD: Rec_0091226 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0104050 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Cytotoxic Anticancer
MCF-7 cells
50-60 %
Percent inhibition assay
PMID22574992 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22574992/
RECORD: Rec_0107727 VERIFIED: NO
Provenance & Taxonomy
Sus scrofa [Animal]
ACE-inhibitory peptide
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperPeptides with angiotensin I converting enzyme (ACE) inhibitory activity generated from porcine skeletal muscle proteins by the action of meat-borne Lactobacillus. PMID23806758 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23806758/
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