‹ ›
MYP_090041
← PREVIOUS NEXT → BACK
Basic Information
Pleurocidin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C129H192N36O29
Standard
Sequence
GWGSFFKKAAHVGKHVGKAALTHYL
Physicochemical Analysis
2711.13 Da
10.18
4.02
3.65
0.1607
-0.07
0.59
0.19
4.97
70.40
0.1600
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1028.32
-7.01
37.0
36.0
87.0
194.0
8.0
24.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0150658 VERIFIED: YES
Provenance & Taxonomy
Winter flounder [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Escherichia coli DC2
2 μM
MIC
PaperIsolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretion of winter flounder.
RECORD: Rec_0159292 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Pleurocidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus Methicillin resistant clinical isolate
8 μg/mL
MIC
PMID9115266;10898673;12950255;12878506;30508627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9115266/
RECORD: Rec_0160673 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/20798581/ PMID20798581 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20798581/
RECORD: Rec_0164219 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Pleurocidin
8265
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antitrypanosomal
Trypanosoma brucei 427 (procyclic form)
27.7 μM
IC50; Alamar Blue assay
PaperAntimicrobial peptide killing of African trypanosomes PMID21517904 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21517904/
RECORD: Rec_0170530 VERIFIED: YES
Provenance & Taxonomy
Winter flounder [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Gram-positive Bacillus subtilis
1.1-2.2 μM
MIC
PaperIsolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretion of winter flounder.
FIRST PREV 1 ... 7 8 9 10 11 ... 23 NEXT LAST
Showing 5 records on this page · Page 9 of 23