‹ ›
MYP_090041
← PREVIOUS NEXT → BACK
Basic Information
Pleurocidin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C129H192N36O29
Standard
Sequence
GWGSFFKKAAHVGKHVGKAALTHYL
Physicochemical Analysis
2711.13 Da
10.18
4.02
3.65
0.1607
-0.07
0.59
0.19
4.97
70.40
0.1600
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1028.32
-7.01
37.0
36.0
87.0
194.0
8.0
24.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0142019 VERIFIED: YES
Provenance & Taxonomy
Pleuronectes americanus [Animal]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Pseudomonas aeruginosa ATCC 27853
0.701 μM
Crystal violet assay
PaperAntimicrobial peptide pleurocidin synergizes with antibiotics through hydroxyl radical formation and membrane damage, and exerts antibiofilm activity PMID22921812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22921812/
RECORD: Rec_0143330 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Pleurocidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Refer PubMed 9115266 :-Escherichia coli
62.5 μg/mL
MIC
PMID9115266;10898673;12950255;12878506;30508627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9115266/
RECORD: Rec_0144536 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Pleurocidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Candida albicans Clinical isolate
16 μg/mL
MIC
PMID9115266;10898673;12950255;12878506;30508627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9115266/
RECORD: Rec_0146100 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Pleurocidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa K799 parent of Z61
8 μg/mL
MIC
PMID9115266;10898673;12950255;12878506;30508627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9115266/
RECORD: Rec_0146117 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Human erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/18779649/ PMID18779649 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18779649/
FIRST PREV 1 ... 6 7 8 9 10 ... 23 NEXT LAST
Showing 5 records on this page · Page 8 of 23