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MYP_090041
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Basic Information
Pleurocidin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C129H192N36O29
Standard
Sequence
GWGSFFKKAAHVGKHVGKAALTHYL
Physicochemical Analysis
2711.13 Da
10.18
4.02
3.65
0.1607
-0.07
0.59
0.19
4.97
70.40
0.1600
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1028.32
-7.01
37.0
36.0
87.0
194.0
8.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0070904 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 76.0%, E 0.0%, T 16.0%, C 8.0% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Antiparasitic Toxic Antimicrobial Hemolytic Anti-Gram-positive Antitrypanosomal Anti-Gram-negative Chemotactic Antibiofilm
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0073185 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pasteurella haemolytica
4.4-8.8 μM
MIC
PMID9115266 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9115266/
RECORD: Rec_0074300 VERIFIED: YES
Provenance & Taxonomy
Pleuronectes americanus [Animal]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Propionibacterium acnes ATCC 6919
1.402 μM
Crystal violet assay
PaperAntimicrobial peptide pleurocidin synergizes with antibiotics through hydroxyl radical formation and membrane damage, and exerts antibiofilm activity PMID22921812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22921812/
RECORD: Rec_0077500 VERIFIED: YES
Provenance & Taxonomy
Winter flounder [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Staphylococcus epidermidis
8 μM
MIC
PaperIsolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretion of winter flounder.
RECORD: Rec_0089456 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Pleurocidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Refer PubMed 9115266 :-Escherichia coli
50.0 μg/mL
MIC
PMID9115266;10898673;12950255;12878506;30508627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9115266/
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