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MYP_090041
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Basic Information
Pleurocidin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C129H192N36O29
Standard
Sequence
GWGSFFKKAAHVGKHVGKAALTHYL
Physicochemical Analysis
2711.13 Da
10.18
4.02
3.65
0.1607
-0.07
0.59
0.19
4.97
70.40
0.1600
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1028.32
-7.01
37.0
36.0
87.0
194.0
8.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0224686 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Pleurocidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis Clinical isolate
8 μg/mL
MIC
PMID9115266;10898673;12950255;12878506;30508627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9115266/
RECORD: Rec_0228508 VERIFIED: YES
Provenance & Taxonomy
Winter flounder [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Staphylococcus aureus
17.7-35 μM
MIC
PaperIsolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretion of winter flounder.
RECORD: Rec_0237172 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
2.5
PaperSung W. S., Lee D. G.. Pleurocidin- derived antifungal peptides with selective membrane-disruption effect. Bioche. Biophys. Res. Commun., 2008, 369, 858-861.
RECORD: Rec_0244949 VERIFIED: YES
Provenance & Taxonomy
Pleuronectes americanus [Animal]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Escherichia coli O-157 / ATCC 43895
0.701 μM
Crystal violet assay
PaperAntimicrobial peptide pleurocidin synergizes with antibiotics through hydroxyl radical formation and membrane damage, and exerts antibiofilm activity PMID22921812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22921812/
RECORD: Rec_0245762 VERIFIED: YES
Provenance & Taxonomy
Winter flounder [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
C. aquatilis
2.2-4.4 μM
MIC
PaperIsolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretion of winter flounder.
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