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MYP_089962
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Basic Information
HCV gp (692706), E2-78
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
15 amino acids
C80H126N22O22S
Standard
Sequence
GLLHLHQNIVDVQYM
Physicochemical Analysis
1780.06 Da
5.97
-1.07
-1.37
-0.0710
0.27
0.46
0.26
47.21
142.67
0.0667
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
714.88
-4.17
23.0
24.0
58.0
125.0
3.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0079499 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Hepatitis C virus (HCV)
PMID28638089 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28638089/
RECORD: Rec_0125570 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Entry inhibition
HCV (Hepatitis C virus) | Huh7.5/CD81 cells
0.001-0.005 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2. | Yin P, Zhang L, Ye F, Deng Y, Lu S, Li YP, Zhang L, Tan W. | A screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2. | DOI:10.1038/s41598-017-04274-8 | PMID:28638089 PMID28638089 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28638089/
RECORD: Rec_0215810 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HCV(Hepatitis C virus):inhibition of HCVcc infection in Huh7
PMID28638089 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28638089/
RECORD: Rec_0273036 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID28638089 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28638089/
RECORD: Rec_0317691 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
5-CD81 cells
PMID28638089 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28638089/
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