Peptide Database

Peptide NameR-spondin-4

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length209 amino acids

Chemical FormulaC1000H1620N338O296S22

DescriptionStandard

        LYRRKKQAGTGLGGNCTGCVICSEENGCSTCQQRLFLFIRREGIRQYGKCVHDCPLGFFGIRGQEANRCKKCGATCESCFSQDFCIRCKRRFHLYKGKCLPSCPPGTLTHQSTRECQEECEPSPWGSWSPCIHNGKTCGSGWGLETRVREAGPAKQEETASCRVLSESRKCPIKRLCPGERNPRQKNRKDRRQRKDRKLERRPHQRGSQ
    

Molecular Weight23819.08 Da

Isoelectric Point (pI)9.54

Net Charge (pH 7.0)23.01

Net Charge (pH 7.4) 22.17

Charge Density (pH 7.0) 0.1101

GRAVY Index-1.00

Hydrophobic Moment 0.73

Boman Index-0.33

Instability Index64.32

Aliphatic Index 43.88

Aromaticity 0.0622

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 22345.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0286695 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID10090

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsAsparagine residue at position 15 is N-linked glycosylated; disulfide bonds between Cysteine residues at positions 120 and 162; 131 and 138; 171 and 177

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetLGR6 (Human)

Activity7 nM

MethodIC50