Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length439 amino acids

Chemical FormulaC2226H3512N604O598S11

DescriptionStandard

        TNPGFVVRITQAGLDYAHQHGIRILEEELGQLKLQDISGDFRVLRVGKVRYELSRLQLRSFHLPHSYISLVPSVGLQVSISNAFADLSGNWRVKIYFIRDHGSFDLKVENVYIKIDLQLGSDPLGKPTIDTSACSTRISRVHVRFSGRLGWLYNLFHGAVESRFRKILESQVCELVAMSVHRELQPYLRTLPATARSLDVDLKRIPSPPAALLLHLPPSLPPSSQGEFFSLAHRSAVPFSPLPLALPPDHSHMVYFGVSSYFFTTGPALPPWSSCCTQVLLPAKQKPPPGGLCCCPHPVPAPLQLERMYPNAPMTFRLSAPSAPFLSIEPQGLSLRPVVDVQAYAVLPGSEPVPLFLLSLVRNVSAVVDVRSGHIVGSLKVGRIKFTLKQSNVGTFQLVFLLLQPSSHILSVPERLNEGFPLPLPDRIQLSKILVRFHQ
    

Molecular Weight48656.10 Da

Isoelectric Point (pI)9.54

Net Charge (pH 7.0)13.76

Net Charge (pH 7.4) 12.58

Charge Density (pH 7.0) 0.0313

GRAVY Index0.09

Hydrophobic Moment 0.72

Boman Index0.11

Instability Index55.86

Aliphatic Index 104.74

Aromaticity 0.0843

Extinction Coeff. Reduced 32890.00

Extinction Coeff. Oxidized 33265.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0130910 VERIFIED: NO

Provenance & Taxonomy

OrganismDryobates pubescens [Animal]

FamilyBPI/LBP

Tax ID118200

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria