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MYP_089746
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Basic Information
P5 (Derived from Octa 2)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
9 amino acids
C74H102N28O10
Standard
Sequence
RRWWRWWRR
Physicochemical Analysis
1543.78 Da
12.00
4.76
4.56
0.5289
-2.90
1.19
-1.05
263.47
0.00
0.4444
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
668.78
-1.51
29.0
15.0
45.0
112.0
8.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024038 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
5.6 μM
MIC
PaperModulating short tryptophan- and arginine-rich peptides activity by substitution with histidine. Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024. PMID: 28372989. PMID28372989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28372989/
RECORD: Rec_0041455 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
3 μM
MIC
PaperModulating short tryptophan- and arginine-rich peptides activity by substitution with histidine. Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024. PMID: 28372989. PMID28372989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28372989/
RECORD: Rec_0049001 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
human RBCs
33.33 μM
Hemolysis
PMID28372989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28372989/
RECORD: Rec_0082043 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
PaperModulating short tryptophan- and arginine-rich peptides activity by substitution with histidine. Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024. PMID: 28372989. PMID28372989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28372989/
RECORD: Rec_0089989 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
1 μg/mL
MIC
PMID28372989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28372989/
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