Peptide Database

Peptide NameSLAY-screened peptide P4884

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC92H151N35O32

DescriptionStandard

        HARDPTDATSSRRTRLSNAF
    

Molecular Weight2259.40 Da

Isoelectric Point (pI)11.52

Net Charge (pH 7.0)1.85

Net Charge (pH 7.4) 1.59

Charge Density (pH 7.0) 0.0925

GRAVY Index-1.29

Hydrophobic Moment 0.37

Boman Index-0.48

Instability Index57.40

Aliphatic Index 34.50

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1122.78

LogP -17.57

H-bond Donors 42.0

H-bond Acceptors 35.0

Rotatable Bonds 72.0

Heavy Atoms 159.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0299466 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/