Peptide Database

Peptide NameSLAY-screened peptide P4044

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H157N23O24S2

DescriptionStandard

        PLTCPAILVRPSFLAPCYGF
    

Molecular Weight2165.62 Da

Isoelectric Point (pI)8.44

Net Charge (pH 7.0)0.94

Net Charge (pH 7.4) 0.85

Charge Density (pH 7.0) 0.0469

GRAVY Index1.01

Hydrophobic Moment 0.26

Boman Index0.41

Instability Index59.27

Aliphatic Index 102.50

Aromaticity 0.1500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 698.45

LogP -3.01

H-bond Donors 26.0

H-bond Acceptors 27.0

Rotatable Bonds 59.0

Heavy Atoms 152.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0064528 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/