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MYP_089640
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Basic Information
Alyteserin-1a
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
23 amino acids
C104H175N29O28
Standard
Sequence
GLKDIFKAGLGSLVKGIAAHVAN
Physicochemical Analysis
2279.68 Da
9.70
1.85
1.59
0.0802
0.63
0.49
0.30
-12.99
127.39
0.0435
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
910.88
-7.85
31.0
31.0
78.0
161.0
2.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0060886 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Alyteserin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
25.0 μM
MIC
PaperJ.M. Conlon et al. / Peptides 30 (2009) 1069-1073. The alyteserins: Two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae)
RECORD: Rec_0089934 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
200 μM
MIC
PMID19463738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19463738/
RECORD: Rec_0118144 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
25 μM
MIC
PMID19463738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19463738/
RECORD: Rec_0134044 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Plant]
Alyteserin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Hemolytic
-1a induced a hemolysis of 11% at the concentration of 100 μM
100 μM
Hemolysis
PMID19463738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19463738/
RECORD: Rec_0170947 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Plant]
Alyteserin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
25 μM
MIC
PMID19463738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19463738/
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