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MYP_089613
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Basic Information
Chionodracine [F1W; H4,15,17K; I9K; S11,21K]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C122H205N33O25
Standard
Sequence
WFGKLYRGKTKVVKKVKGLLKG
Physicochemical Analysis
2534.14 Da
10.82
7.75
7.54
0.3524
-0.43
0.69
-0.11
-35.49
92.73
0.1364
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
974.71
-4.33
36.0
33.0
91.0
180.0
4.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0169623 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
ESBL Escherichia coli
6.25 μg/mL
MIC
PaperFish-derived antimicrobial peptides: Activity of a chionodracine mutant against bacterial models and human bacterial pathogens.
RECORD: Rec_0183035 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
COOH
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae KPC
12.5-25 μg/mL
MIC
PMID30790604 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30790604/
RECORD: Rec_0207398 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0222819 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
COOH
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus methicillin-resistant Staphylococcus aureus
25-50 μg/mL
MIC
PMID30790604 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30790604/
RECORD: Rec_0244591 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 30790604 PMID30790604 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30790604/
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