Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2305H3628N618O646S11

DescriptionStandard

        TNPGFVVRITQAGLDYAHQQGIAVLEKELAQLKLPDISGDFRIRHVGKVHYEISRLDLRSFHLPYSRISLVPNVGLQVSISNAFAELDGNWRVKIYFIRDRGSFDLKVENIYIKIILKLGSDASGKPTIDTSDCSTRISNVRVHFSGKFGWLYNLFHSAIESRFRRTLESRVCKNVVSSVHSELQPYLQTLPVTANIGTMAGIDYSLVAPPTATAQSLDVDLKGEFFSRAHRSAVPFRPLVLALPPDHDRMVYFGASSYFFNTAGFAYQAAGALVFEITDSMIPKDADFHLETSTFSAFVPQLEKMYPDMMMKLRLSTPSAPFLNIGPGGLSLKPVVDIQAYAILPNSSLAPLFLLSLVSNVSAVIDIKSSHIVGSLNVGRMKLSLKHSDVGTFQVRTLQSIMNILASNILLPQLNARLEEGFPLPLPDRIQLSNILLRFHQNFLLLGADVHYQPR
    

Molecular Weight50685.93 Da

Isoelectric Point (pI)9.13

Net Charge (pH 7.0)6.63

Net Charge (pH 7.4) 5.62

Charge Density (pH 7.0) 0.0145

GRAVY Index0.09

Hydrophobic Moment 0.68

Boman Index0.11

Instability Index41.67

Aliphatic Index 103.90

Aromaticity 0.0943

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0323828 VERIFIED: NO

Provenance & Taxonomy

OrganismFregata magnificens [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria