Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length394 amino acids

Chemical FormulaC1987H3033N525O576S22

DescriptionStandard

        MEQRRGSDGVEEWVRWSRGEGQMEQRRGSDGAEEWVRWSRGCRGGSNGDIINSMINNCKWPTATTTHSLSELRVNPTVILCVCFSMHITKLDFPEPEVHFSPPVSGLDLSVSGLSMALTGDWSTHLGAIHDGGTFDMAIFDLSLRSFLGLDRDSSGHPSVSSVYCEVDIQTVNMQFYGGARYTHVCPCVENAIQSLERHLQAINSTAISYFHCCQGEFYSPESHRDPPFVAPPFSLPVQSTYMLSVGVSEYTANSASFAYYISGHLQALINDSMIPSYCPIRLNTSSMGRFIPQLSQMYPDLLMVLQVYARQTPLFTFQPGFVKLDLLSAIKAFVVQANSTLTPVFKLRIIHLTKKSALFFSFTLSLDSSEIGLFKVNYNKQIKYKLHYVIFFF
    

Molecular Weight44196.94 Da

Isoelectric Point (pI)6.35

Net Charge (pH 7.0)-3.42

Net Charge (pH 7.4) -4.52

Charge Density (pH 7.0) -0.0087

GRAVY Index-0.04

Hydrophobic Moment 0.75

Boman Index0.10

Instability Index48.76

Aliphatic Index 82.11

Aromaticity 0.1168

Extinction Coeff. Reduced 55350.00

Extinction Coeff. Oxidized 55975.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0254357 VERIFIED: NO

Provenance & Taxonomy

OrganismPeriophthalmus magnuspinnatus [Bacterium]

FamilyBPI

Tax ID409849

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence