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MYP_089364
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
40 amino acids
C189H273N53O56S7
Standard
Sequence
GFGCNGPWDEDDMQCHNHCKSIKGYKGGYCAKGGFVCKCY
Physicochemical Analysis
4407.97 Da
7.77
0.87
0.47
0.0218
-0.69
0.36
-0.02
13.82
19.50
0.1500
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1752.07
-19.15
65.0
66.0
143.0
305.0
10.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0301039 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Pseudoplectania nigrella [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
It is the first fungal defensin identified in the secretome of the ascomycete P. nigrella. Chemical modification: three disulfide bonds: C4-C30, C15-C37, and C19-C39
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
Staphylococcus aureus MSSA 5 strains
4-32 μg/mL
MIC
Unspecified 61 h
PaperPlectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
RECORD: Rec_0312853 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 22.5%, E 20.0%, T 27.5%, C 30.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiviral Antimicrobial Antifungal Anti-Gram-positive
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0345354 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Pseudoplectania nigrella [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
It is the first fungal defensin identified in the secretome of the ascomycete P. nigrella. Chemical modification: three disulfide bonds: C4-C30, C15-C37, and C19-C39
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
1 strain
>128 μg/mL
MIC
Unspecified 61 h
PaperPlectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
RECORD: Rec_0406858 VERIFIED: YES
Provenance & Taxonomy
Pseudoplectania nigrella [Fungus]
invertebrate defensin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
4-30; 15-37; 19-39
Bio-Activity Profile
Antimicrobial invertebrate defensin family Antibacterial Host defense Defensin-like
PaperPDB 3E7U structural record; X-ray; 1.35 A; chain X; residues 1-40
RECORD: Rec_0412161 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Pseudoplectania nigrella [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
It is the first fungal defensin identified in the secretome of the ascomycete P. nigrella. Chemical modification: three disulfide bonds: C4-C30, C15-C37, and C19-C39
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
C. jeikeium 3 strains
1-2 μg/mL
MIC
Unspecified 61 h
PaperPlectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
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