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MYP_089338
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Basic Information
Kassinatuerin-2Md (Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
20 amino acids
C96H159N25O24
Standard
Sequence
IIGAIAAALPHVINAIKNTF
Physicochemical Analysis
2047.44 Da
8.76
0.85
0.59
0.0423
1.27
0.55
0.52
12.56
156.50
0.0500
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
768.54
-4.75
25.0
26.0
64.0
145.0
3.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0172249 VERIFIED: YES
Provenance & Taxonomy
Kassina maculata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Toxicity
At the same concentration, the peptide can cause hemolysis (horse blood) by ~50%
PaperA family of kassinatuerin-2 related peptides from the skin secretion of the African hyperoliid frog, Kassina maculata.
RECORD: Rec_0205151 VERIFIED: YES
Provenance & Taxonomy
Kassina maculata [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Hemolytic
horse erythrocytes
PaperPubMed PMID: 19427345 PMID19427345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19427345/
RECORD: Rec_0250929 VERIFIED: NO
Provenance & Taxonomy
Kassina maculata [Animal]; Hylambates maculatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0270298 VERIFIED: YES
Provenance & Taxonomy
Kassina maculata [Animal]
Kasseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
16.0 μM
MIC
PaperL. Wang et al. / Peptides 30 (2009) 1428-1433. A family of kassinatuerin-2 related peptides from the skin secretion of the African hyperoliid frog, Kassina maculata Evidence URLhttps://www.uniprot.org/uniprotkb/C7C1L1/entry
RECORD: Rec_0290097 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Horse erythrocytes
120 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/19427345/ PMID19427345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19427345/
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