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MYP_089303
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Basic Information
Ala-6-fenycin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Standard
10 amino acids
C57H83N11O20
Standard
Sequence
EKYTEAPEYI
Physicochemical Analysis
1242.33 Da
4.25
-2.16
-2.34
-0.2160
-1.30
0.41
-0.11
56.41
49.00
0.2000
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
515.04
-2.67
17.0
18.0
38.0
88.0
3.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0029114 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Lipidation
Esterification
bacteriocin-like inhibitory substances. An acyl chain (C15 to C17 carbons) is attached to E1, residue 2 is an ornithine (represented as K), and the carboxylic group of C-terminal I10 forms an ester bond with the side chain of Y3
Bio-Activity Profile
Antimicrobial Antiviral
(Bacillus subtilis, L. acidophilus ATCC 4356, B. linens, C. Wmi NCTC 7547, Listeria monocytogenes, L. innocua, Bacillus cereus, L. innocua ATCC 33090, L. innocua 1572, L. ivanovii 5 NCTC 11007, L. seeligeri AC 82/4, L. welshimeri AC 73/2, (Motta et al., 2007b)
PaperAntiviral activity of a Bacillus sp. P34 peptide against pathogenic viruses of domestic animals.
RECORD: Rec_0035947 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0068539 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Gram-positive
PaperPubMed PMID: 22847390 PMID22847390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22847390/
RECORD: Rec_0220365 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp. strain [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antiviral
Gram-positive
PaperPubMed PMID: 25477947 PMID25477947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25477947/
RECORD: Rec_0237264 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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