Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length445 amino acids

Chemical FormulaC2161H3520N602O608S14

DescriptionStandard

        MARGPEGVRSWPALVLLAAVVTAETEATNPGFTTRISQKGLDYACQQGVAVLQKELEKIRIPDVSGKFKLRPFGKGHYNFHSLVVRSFQLPNPQIRLQPNVGLRVSISNANVRIGGRWKARKGFIKVRGKFDLSVEGVSISADLKLGSVPASGRATVTCSSCSSNINRARLRVSGILGWLLKLFHKRIESSLRNTMNSKICQVLTSSVSSKLQPYVETLPLKERLDSVAGIDYSLVAPPRATADSLDMQLKGEFYNVASPSPPPFMPPPMAIPSLHDRMIYLAISDYLFNTAALVYQQAGAFGLTLRDDMIPKESKSRLTTKFLGKALPQVAKMFPNMNVQLTLSVSSPPHLTTRPTGIALTAAVDLQAFAILPNSSLASLFLLGLKLNTSAKIGTKADKLVGELTLGRLILELKHSNIGSFPVSLAPPRPHPGALVSRCLGSVA
    

Molecular Weight48111.64 Da

Isoelectric Point (pI)10.17

Net Charge (pH 7.0)27.08

Net Charge (pH 7.4) 26.35

Charge Density (pH 7.0) 0.0609

GRAVY Index0.04

Hydrophobic Moment 0.66

Boman Index0.07

Instability Index43.09

Aliphatic Index 100.16

Aromaticity 0.0629

Extinction Coeff. Reduced 28420.00

Extinction Coeff. Oxidized 28670.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0141611 VERIFIED: NO

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyBPI/LBP

Tax ID9986

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria