Peptide Database

Peptide NameWNV(1968-1972)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus

Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Helicase inhibition

Standard StatusStandard

Sequence Length5 amino acids

Chemical FormulaC19H32N6O10

DescriptionStandard

        SQVGD
    

Molecular Weight504.49 Da

Isoelectric Point (pI)4.30

Net Charge (pH 7.0)-1.54

Net Charge (pH 7.4) -1.75

Charge Density (pH 7.0) -0.3071

GRAVY Index-0.80

Hydrophobic Moment 0.53

Boman Index-0.07

Instability Index14.46

Aliphatic Index 58.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 280.34

LogP -4.64

H-bond Donors 9.0

H-bond Acceptors 9.0

Rotatable Bonds 16.0

Heavy Atoms 35.0

Ring Count 0.0

Amide Bonds 5.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0383832 VERIFIED: YES

Provenance & Taxonomy

OrganismHepatitis C virus [Virus]

FamilyVirus-derived peptide

Tax ID3052230;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Replication inhibitor

TargetHepatitis C virus (Replication); Vero

Activity500 μM

MethodHelicase assay

PaperViral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). | Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A. | Biochem Pharmacol. 2008 | PMID:18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/

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