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MYP_089055
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Basic Information
Antimicrobial peptide PGQ (PGQ; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C112H194N30O31
Standard
Sequence
GVLSNVIGYLKKLGTGALNAVLKQ
Physicochemical Analysis
2456.92 Da
10.00
2.76
2.55
0.1148
0.55
0.55
0.26
-5.33
142.08
0.0417
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1000.64
-8.92
34.0
34.0
85.0
173.0
1.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0186166 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
62-250 μg/mL
MIC
PMID1717472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1717472/
RECORD: Rec_0189837 VERIFIED: NO
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Non-hemolytic Non-ribosomal
Qualitative functional evidence
PMID1717472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1717472/; https://www.uniprot.org/uniprotkb/P39080/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0199683 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperMoore K. S., Bevins C. L., Brasseur M. M., Tomassini N., Turner K., Eck H., Zasloff M.. Antimicrobial peptides in the stomach of Xenopus laevis. J. Biol. Chem., 266, 19851-19857, 1991.
RECORD: Rec_0227156 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Streptococcus faecalis
250-500 μg/mL
MIC
PMID1717472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1717472/
RECORD: Rec_0227686 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
62-250 μg/mL
MIC
PMID1717472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1717472/
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