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MYP_089055
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Basic Information
Antimicrobial peptide PGQ (PGQ; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C112H194N30O31
Standard
Sequence
GVLSNVIGYLKKLGTGALNAVLKQ
Physicochemical Analysis
2456.92 Da
10.00
2.76
2.55
0.1148
0.55
0.55
0.26
-5.33
142.08
0.0417
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1000.64
-8.92
34.0
34.0
85.0
173.0
1.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003408 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa
250-500 μg/mL
MIC
PMID1717472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1717472/
RECORD: Rec_0018493 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Antimicrobial
Candida albicans 14053
250-500 μg/mL
MIC
PaperAntimicrobial peptides in the stomach of Xenopus laevis.
RECORD: Rec_0033167 VERIFIED: NO
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus faecalis, Candida albicans
RECORD: Rec_0049238 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0068996 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 33.3%, E 0.0%, T 45.8%, C 20.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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