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MYP_089050
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Basic Information
Human obestatin
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Gastrointestinal bioactivity
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Sleep regulation
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
23 amino acids
C116H175N31O34
Standard
Sequence
FNAPFDVGIKLSGVQYQQHSQAL
Physicochemical Analysis
2547.82 Da
6.74
-0.15
-0.41
-0.0067
-0.16
0.41
0.14
30.38
84.78
0.1304
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1062.87
-10.75
34.0
35.0
82.0
181.0
5.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0197813 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Proghrelin-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Hormonal Appetite regulation
Mouse plasma with protease inhibitor cocktail
HPLC, LC-UV/MS
95.8 [89.4, 103.3] min
PaperIn vitro metabolic stability of obestatin: kinetics and identification of cleavage products
RECORD: Rec_0245694 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0267963 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 13.0%, E 0.0%, T 60.9%, C 26.1% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Drug Delivery Vehicle Blood-Brain Barrier
PaperBrainpeps: the blood-brain barrier peptide database PMID22205159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22205159/
RECORD: Rec_0349047 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Obestatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation Sleep regulation Wake regulation Feeding regulator
Mammalian: 1.1 hour; Yeast: 3 min; E. coli: 2 min
RECORD: Rec_0422561 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Motilin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Gastrointestinal
Evidence URLhttps://www.uniprot.org/uniprotkb/GHRL_HUMAN/entry
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