Peptide Database

Peptide NameUstekinumab

Function Ontology

Anticancer

Standard StatusStandard

Sequence Length226 amino acids

Chemical FormulaC1083H1678N286O334S9

DescriptionStandard

        EVQLVQSGAEVKKPGESLKISCKGSGYSFTTYWLGWVRQMPGKGLDWIGIMSPVDSDIRYSPSFQGQVTMSVDKSITTAYLQWNSLKASDTAMYYCARRRPGQGYFDFWGQGTLVTVSSSSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTH
    

Molecular Weight24337.21 Da

Isoelectric Point (pI)9.15

Net Charge (pH 7.0)7.05

Net Charge (pH 7.4) 6.60

Charge Density (pH 7.0) 0.0312

GRAVY Index-0.25

Hydrophobic Moment 0.58

Boman Index0.06

Instability Index51.90

Aliphatic Index 67.61

Aromaticity 0.1018

Extinction Coeff. Reduced 47900.00

Extinction Coeff. Oxidized 48150.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0101473 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer

Half-LifeFollowing administration of a single subcutaneous dose of 45 mg or 90 mg in patients with psoriasis, the median half-life was 19.8 days and 21.2, respectively.