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MYP_088936
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Basic Information
Adamtsostatin-like-4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic
Standard
20 amino acids
C93H157N39O28S2
Standard
Sequence
SPWSQCSVRCGRGQRSRQVR
Physicochemical Analysis
2333.62 Da
11.82
4.44
4.20
0.2220
-1.30
0.52
-0.56
69.11
29.00
0.0500
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1142.91
-17.64
45.0
35.0
77.0
162.0
3.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0049132 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperA systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13775-13780. doi: 10.1073/pnas.0803241105. PMID: 18780781. PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
RECORD: Rec_0083014 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Thrombospondin type-1 repeat
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic
Endothelial screening context
PaperSupporting Information for Karagiannis and Popel, PNAS (10.1073/pnas.0803241105) PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
RECORD: Rec_0109255 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
CCN family TSR peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic
HUVEC
Endothelial migration assay
PaperPeptides derived from type I thrombospondin repeat-containing proteins of the CCN family inhibit proliferation and migration of endothelial cells PMID17707681 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17707681/
RECORD: Rec_0189347 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PaperA systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13775-13780. doi: 10.1073/pnas.0803241105. PMID: 18780781. PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
RECORD: Rec_0233109 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperA systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13775-13780. doi: 10.1073/pnas.0803241105. PMID: 18780781. PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
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