Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2237H3639N569O643S18

DescriptionStandard

        MFLWCVLVLVSLLSVATGTSAGVKARITQKGLEYGRAIGIESLQQKLRTIQLKDVSGTEKLAIGKVEYSITGMQIVNLGLPKSALRLVAGTGVMLSVGDAYISLRGNWRVKYSWIIKASGSFELAVSELAISTTIAVKSDVTGRPTVSVTKCEATVGSVKVRFISHTIYLLFQICPLVTASIAEMNKNLKTLNVLAKVDQYAELEYSMVESPVISNAMIDLGLKGEFYNIGQHKEPPFSPRPFLLPSQDTNMLYIGVSAFSINSAGFVYHRAGALCLYITNDMIPSGSLNRLNTRTFGKFIPQIGNMSPGLMMKLLVETVKEPIVTLEPNNMTVQASSKVTAYAIQPNSILSPLFVLKLEASVSAHIYVTGLKLAGHVTLNKIDMSLAESYVGPFQVTSLEDILTTVVKDVIIPKVNAGVKEGYPLPAIGKMQLVKSQLQVLKDYLLIGTDVTLTG
    

Molecular Weight49370.42 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)9.92

Net Charge (pH 7.4) 9.28

Charge Density (pH 7.0) 0.0218

GRAVY Index0.32

Hydrophobic Moment 0.76

Boman Index0.19

Instability Index26.03

Aliphatic Index 113.03

Aromaticity 0.0702

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40590.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0241666 VERIFIED: NO

Provenance & Taxonomy

OrganismSinocyclocheilus grahami (Dianchi golden-line fish) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria