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MYP_088855
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Basic Information
Bovicin HJ50 (Bacteriocin; Predicted)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
33 amino acids
C147H248N42O46S4
Standard
Sequence
ADRGWIKTLTKDCPNVISSICAGTIITACKNCA
Physicochemical Analysis
3468.06 Da
8.53
1.76
1.50
0.0532
0.30
0.57
0.11
24.98
91.82
0.0303
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1423.64
-17.01
54.0
52.0
113.0
239.0
3.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0073713 VERIFIED: YES
Provenance & Taxonomy
Streptococcus bovis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0087134 VERIFIED: YES
Provenance & Taxonomy
Streptococcus bovis HJ50 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis AS1.1087
PMID14702402 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14702402/
RECORD: Rec_0095240 VERIFIED: YES
Provenance & Taxonomy
Streptococcus bovis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
There are two thioether rings (T8-C13 and T10-C32) and one unique disulfide bond between C21-C29 (Lin et al. 2010 Microbiol Res 166: 146-154)
Bio-Activity Profile
Antimicrobial
Bacillus megaterium AS1.941, Bacillus subtilis AS1.1087, L. curvatus LTH1174, L. mesenteroides AS1.2, L. dextranicum 181
PaperBovicin HJ50, a novel lantibiotic produced by Streptococcus bovis HJ50
RECORD: Rec_0109774 VERIFIED: YES
Provenance & Taxonomy
Streptococcus thermophilus SBT1277 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus cereus
PMID17381740 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17381740/
RECORD: Rec_0113060 VERIFIED: YES
Provenance & Taxonomy
Streptococcus bovis HJ50 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Leuconostoc mesenteroides AS1.2
PMID14702402 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14702402/
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