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MYP_088825
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Basic Information
Frenatin-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
15 amino acids
C64H113N17O19
Standard
Sequence
GLLGTLGNLLNGLGL
Physicochemical Analysis
1424.68 Da
5.53
-0.24
-0.44
-0.0160
1.13
0.41
0.55
-12.01
182.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
577.13
-5.20
19.0
19.0
48.0
100.0
0.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0156631 VERIFIED: YES
Provenance & Taxonomy
Litoria infrafrenata [Animal]
Frenatin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0188188 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID9225251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9225251/
RECORD: Rec_0207205 VERIFIED: YES
Provenance & Taxonomy
Litoria infrafrenata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Micrococcus luteus at 50 ug/ml (see ref)
PaperThe structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata
RECORD: Rec_0269947 VERIFIED: NO
Provenance & Taxonomy
Litoria infrafrenata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 2020/0048303 A1 Evidence URLhttps://patents.google.com/patent/US20200048303A1/en PatentUS 2020/0048303 A1
RECORD: Rec_0282737 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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