Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length479 amino acids

Chemical FormulaC2459H3821N599O718S17

DescriptionStandard

        LTGPQRTGEMMKVWSFILLLSWFTLQLDANPGLKVRITQKGLDFGKEIGMEILKERIKEESFPDWNDSEKFGLSEINYHLSGIRIDTIEFPNTAISLIPGTGIKLTIENAYVIIKANWNIRSWMFKGSGRTTVVISGVSITAMLVMSMDSTGHPSISLDSCQMIASGVEVKLHGKNSWFYNMFTKFLKKSIHRILDSNSCPNLRQEIEIIDMELRILQILMQIDDFAQIDYSLVKSPAVFQSYIDLDLQGTTYPVGNYPAHPYVPVPFALQDSSDSMLYLAVSKYSFQTTVFAYYTTGAFNIIVTDEVCSYFNITTETFGSIIPEVAQYYAESQPVMLNLTATKTPVISLQTDAFTIEIHGSVEVLAVLPDATTQSLFTVNITTNSSINLTLFDQKLIGSLCLNRFQLSLADSNLGFFEISLLENFFFYILHSEIIPSANAKLTKGFPLPNLANISLKKPLIKVEQGYLWISTDVNYEQ
    

Molecular Weight53808.33 Da

Isoelectric Point (pI)5.07

Net Charge (pH 7.0)-12.62

Net Charge (pH 7.4) -13.35

Charge Density (pH 7.0) -0.0263

GRAVY Index0.13

Hydrophobic Moment 0.74

Boman Index0.17

Instability Index45.98

Aliphatic Index 101.75

Aromaticity 0.1106

Extinction Coeff. Reduced 65320.00

Extinction Coeff. Oxidized 65570.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0212145 VERIFIED: NO

Provenance & Taxonomy

OrganismAlligator sinensis [Bacterium]

FamilyBPI

Tax ID38654

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence