Peptide Database

Peptide NamePnTx-3-6

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel modulation

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length55 amino acids

Chemical FormulaC248H394N74O78S12

DescriptionStandard

        ACIPRGEICTDDCECCGCDNQCYCPPGSSLGIFKCSCAHANKYFCNRKKEKCKKA
    

Molecular Weight6045.01 Da

Isoelectric Point (pI)8.30

Net Charge (pH 7.0)2.77

Net Charge (pH 7.4) 2.33

Charge Density (pH 7.0) 0.0503

GRAVY Index-0.48

Hydrophobic Moment 0.36

Boman Index-0.15

Instability Index46.09

Aliphatic Index 35.64

Aromaticity 0.0727

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2460.51

LogP -30.91

H-bond Donors 95.0

H-bond Acceptors 94.0

Rotatable Bonds 200.0

Heavy Atoms 412.0

Ring Count 8.0

Amide Bonds 58.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0127641 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted disulphide bond formation between cysteine residues at positions 2 and 16, 9 and 22, 15 and 37, 24 and 35, and 45 and 52

Bio-Activity Profile

Function

Receptor antagonist Ion channel modulation Signaling peptide

TargetCav2.1 (Rat); Cav2.3 (Rat)