Peptide Database

Peptide NameSLAY-screened peptide P5008

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length6 amino acids

Chemical FormulaC33H50N8O8S

DescriptionStandard

        CLHFLS
    

Molecular Weight718.86 Da

Isoelectric Point (pI)6.73

Net Charge (pH 7.0)-0.16

Net Charge (pH 7.4) -0.43

Charge Density (pH 7.0) -0.0271

GRAVY Index1.48

Hydrophobic Moment 0.36

Boman Index0.50

Instability Index23.15

Aliphatic Index 130.00

Aromaticity 0.1667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 257.73

LogP -0.95

H-bond Donors 10.0

H-bond Acceptors 10.0

Rotatable Bonds 21.0

Heavy Atoms 50.0

Ring Count 2.0

Amide Bonds 5.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0298656 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/