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MYP_088698
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Basic Information
MLH40
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Standard
41 amino acids
C209H325N61O58S2
Standard
Sequence
SVALVPHVGMGLETRTETWMSSEGAWKHVQRIETWILRHPG
Physicochemical Analysis
4684.32 Da
6.79
-0.27
-0.64
-0.0065
-0.31
0.69
0.06
57.67
80.73
0.0732
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1888.77
-16.06
68.0
63.0
149.0
330.0
11.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0095291 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Infection inhibition
Dengue virus 4(DENV4) | Vero cells
24.45±1.2 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperA peptide inhibitor derived from the conserved ectodomain region of DENV membrane (M) protein with activity against dengue virus infection. | Panya A, Sawasdee N, Junking M, Srisawat C, Choowongkomon K, Yenchitsomanus PT. | Chem Biol Drug Des. 2015 Nov;86(5):1093-104. | DOI:10.1111/cbdd.12576 | PMID:25891143 PMID25891143 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25891143/
RECORD: Rec_0148854 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Infection inhibition
Dengue virus 2(DENV2) | Vero cells
31.41±1.09 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperA peptide inhibitor derived from the conserved ectodomain region of DENV membrane (M) protein with activity against dengue virus infection. | Panya A, Sawasdee N, Junking M, Srisawat C, Choowongkomon K, Yenchitsomanus PT. | Chem Biol Drug Des. 2015 Nov;86(5):1093-104. | DOI:10.1111/cbdd.12576 | PMID:25891143 PMID25891143 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25891143/
RECORD: Rec_0156214 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Infection inhibition
Dengue virus 3(DENV3) | Vero cells
27.95±1.41 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperA peptide inhibitor derived from the conserved ectodomain region of DENV membrane (M) protein with activity against dengue virus infection. | Panya A, Sawasdee N, Junking M, Srisawat C, Choowongkomon K, Yenchitsomanus PT. | Chem Biol Drug Des. 2015 Nov;86(5):1093-104. | DOI:10.1111/cbdd.12576 | PMID:25891143 PMID25891143 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25891143/
RECORD: Rec_0166040 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
dengue virus 3(DENV3):inhibition of viral infection in Vero cells
27.95±1.41 μM
IC50
PaperPubMed PMID: 25891143 PMID25891143 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25891143/
RECORD: Rec_0170385 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Infection inhibition
Dengue virus 1(DENV1) | Vero cells
30.35±1.25 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperA peptide inhibitor derived from the conserved ectodomain region of DENV membrane (M) protein with activity against dengue virus infection. | Panya A, Sawasdee N, Junking M, Srisawat C, Choowongkomon K, Yenchitsomanus PT. | Chem Biol Drug Des. 2015 Nov;86(5):1093-104. | DOI:10.1111/cbdd.12576 | PMID:25891143 PMID25891143 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25891143/
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